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HYPERLIPIDEMIAS, DIABETES AND DEPRESSION

Author(s)
Saara Ahmad Department of Biological and Biomedical Sciences, The Aga Khan University,Karachi, Pakistan
Rehana Rehman Department of Biological and Biomedical Sciences, The Aga Khan University,Karachi, Pakistan
Saida Haider Neurochemistry and Biochemical Neuropharmacology Research Unit,University of Karachi,Karachi, Pakistan
Zehra Batool Neurochemistry and Biochemical Neuropharmacology Research Unit,University of Karachi,Karachi, Pakistan
Fatima Ahmed Department of Ophthalmology, Liaquat National Hospital and Medical College, Karachi, Pakistan,
Saad Bilal Ahmed Department of Geriatrics, Monash University, Melbourne, Australia
Abstract
Background: Factors causing increased cholesterol levels in the body may include inactivity, obesity, genetic factors and an unhealthy diet. The high colesterol levels or hyperlipidemias may contribute to high concentrations of its precursor triglycerides and low density lipoproteins in plasma of the individuals. High triglyceride levels signal insulin resistance. This study was designed to determine an association of hyperlipidemia and diabetes mellitus with depression. Method: This case-control study involved 30 patients diagnosed with type 2 Diabetes Mellitus (DM) and hyperlipidemia (HL), and 30 non-diabetic healthy individuals having normal glucose tolerance test and no other co-morbidity. All subjects were of 30-50 years age. Blood samples from all participants were collected for determination of the HbA1C and lipid profiles. PQ9 score questionnaire for depression was asked from all subjects. Results: Patients suffering with hyperlipidemias and diabetes mellitus had higher incidence of depression compared to healthy subjects (p<0.05). Conclusion: Depression was more prevalent in hyperlipidemic and diabetic patients.
Publication Details
Page(s) 8-11
DOI DOI not available
Published Journal: Pakistan Journal of Physiology, Volume: 13, Issue: 3, Year: 2017

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Keywords
Depression, serotonin, Diabetes mellitus, hyperlipidemias, tryptophan
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