Academic information system software currently available does not fully apply the quality model as its system instrument. Quality instruments are needed as a determinant of the quality of academic information system software. IS Quality Model is a conceptual quality instrument model that implements and focuses the standardization of usability and security behavior on a website-based academic information system. IS Quality Model consists of Usability-Focused IS Quality Instruments, and SecurityFocused IS quality instrument. Quality Structure and Quality Factors, IS Quality Model and Quality Model Questionnaire Method are the most appropriate methods to describe a proposed IS Quality Model. Usability-Focused IS Quality Instrument are quality instrument IS that that determine usability behavior in academic information system software, namely understandability, learnability, operability, attractiveness, and usability compliance. Six of security-focused IS quality instruments that must be possessed by an academic information system namely privacy, confidentiality, integrity, authentication, availability, and access control. IS Quality Model will provide quality assurance for a software that has a comprehensive quality factor that is easy to learn and use, providing satisfaction in interacting, a high level of reliability, safety, and the availability of information