The need of belongingness is said to be one of the basic human need. The quality of parent-child relationship provides a base to develop long term, intimate and deep emotional bonds among individuals. The current study is aimed to explore the predictive relationship of perception of parental practices and quality of interpersonal relationship with psychological problems among college students. In a quantitative correlation survey research design, 321 participants (54 % boys & 46% girls) from different colleges of Lahore were selected through stratified random sampling. The age range of the participants was 15-20 years (M=17.32; SD=1.00). Three scales Egna Minnen Betraffenda Uppdostran - A (EMBU-A; Gerlsma, Arrindell, Veen, & Emmelkamp, 1991), Interpersonal Difficulties Scale (Saleem, Ihsan, & Mahmood, 2014) and General Health Questionnaire-30 (Goldberg & Williams, 1988) and a demographic form were given to participants. Findings of the study showed that perceived parental rejection and interpersonal problems are the significant predictors of psychological problems in college students. Results are discussed in terms of counseling and cultural perspectives.