The major objective of this study was to evaluate discrepancy in between two antibiotic susceptibility techniques, minimum inhibitory concentration evaluator (M.I.C.E) and disc diffusion. A total of 75AButzleriisolates were tested against ampicillin, tetracycline, ciprofloxacin, erythromycin, cefotaximeand gentamycin. The results revealed that 89.3% and 92% for ampicillin, 22.7% and 26.7% for ciprofloxacin,77.7% and 57.3% for erythromycin,9.4% and 13.3% for tetracycline, 53.3% and 73.3% for cefotaximeand 22.6% and 26.7% for gentamycin, isolates were resistant using M.I.C.E and disc diffusion, respectively. Moreover, multi-drug resistant was noticed in 16% by M.I.C.E and 12% by disc diffusion methods. Fisher's analysis showed that both methods tested were non-significant (P=0.05) for other antibiotics except erythromycin (P=0.0144) and cefotaxime (p=0.0173). In conclusion, tetracycline can be used as a drug of choice to treat infections caused by A. butzleriand either of the methods, disc diffusion or M.I.C.E, can be used for four of the six antibiotics tested.