Staphylococcus Pseudintermedius Isolation from Canine, Bacterial Colonization and Clinical Picture in BALB/c Mouse Model.

D. H. Kalhoro; S. Gao; M. S. Kalhoro; F. Parveen; S.A. Pirzado; Y. J. Liu; M.Tariq

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Staphylococcus Pseudintermedius Isolation from Canine, Bacterial Colonization and Clinical Picture in BALB/c Mouse Model.

Author(s)

D. H. Kalhoro College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China; Faculty of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University,Tandojam, Pakistan

S. Gao College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China

M. S. Kalhoro Faculty of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University,Tandojam, Pakistan

F. Parveen Faculty of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University,Tandojam, Pakistan

S.A. Pirzado Faculty of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University,Tandojam, Pakistan

Y. J. Liu College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China

M.Tariq Faculty of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University, Tandojam-70060, Pakistan

Abstract

Staphylococcus pseudintermedius is an emerging pathogen causing respiratory infection in dogs. In this experiment pathogenicity characteristic of S. pseudintermedius were determined. The research was mainly focused on three aspects including bacterial load, histopathological changes and virulence factors. BALB/c mice were intranasaly inoculated with S. pseudintermedius. The results showed that the bacteria can cause serious neurologic symptoms including walking in circles, bending of neck and produces obvious histopathological changes in lung and brain of the mice. In lungs and brain higher levels of bacterial load was observed during present study. Of all 11 oxacillin-resistant isolates of S. pseudintermedius, 2 carried SCCmec types II-III, 2 carried SCCmec I and 3 carried SCCmec types III according to PCR-based SCCmec typing. Exfoliative toxin (siet), lukS and luk F genes were also identified from the isolates.

Publication Details

Page(s) 422-429

DOI DOI not available

Published Journal: Journal of Animal and Plant sciences, Volume: 27, Issue: 2, Year: 2017

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