Does Anxious Patients Require More Propofol at Induction?.

Syarifah Noor Nazihah Sayed Masri; Raha Abdul Rahman; Azlina Masdar; Wan Rahiza Wan Mat; Nadia Md Nor; Azarinah Izaham

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Does Anxious Patients Require More Propofol at Induction?.

Author(s)

Syarifah Noor Nazihah Sayed Masri Department of Anesthesiology & Intensive Care, Hospital Canselor Tuanku Muhriz, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia

Raha Abdul Rahman Department of Anesthesiology & Intensive Care, Hospital Canselor Tuanku Muhriz, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia

Azlina Masdar Department of Anesthesiology & Intensive Care, Hospital Canselor Tuanku Muhriz, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia

Wan Rahiza Wan Mat Department of Anesthesiology & Intensive Care, Hospital Canselor Tuanku Muhriz, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia

Nadia Md Nor Department of Anesthesiology & Intensive Care, Hospital Canselor Tuanku Muhriz, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia

Azarinah Izaham Department of Anesthesiology & Intensive Care, Hospital Canselor Tuanku Muhriz, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia

Abstract

Background: Preoperative anxiety increases postoperative analgesic requirement, prolongs hospital stay and results in poor patient satisfaction. We investigated the correlation of preoperative state of anxiety on propofol requirement at induction of anesthesia and vital signs. Methodology: This prospective study recruited 52 ASA I and II patients scheduled for surgery under general anesthesia. The Malay version of Generalized Anxiety Disorder-7 questionnaire was used to assess preoperative anxiety state. Anesthesia was induced with propofol infusion using the Schnider protocol to achieve target plasma concentration of 4 µg/ml. Baseline systolic blood pressure and heart rate (HR) prior to induction were recorded. The amount of propofol required until loss of consciousness, and bispectral index (BIS) values immediate post induction were recorded. Pearson’s correlation coefficient was used to assess relationship. Results: There was no correlation between the preoperative state of anxiety and propofol requirement at induction (r = 0.07, p = 0.580), and systolic blood pressure prior to induction (r = 0.23, p = 0.101). However, weak positive correlations were detected between preoperative state of anxiety and the HR prior to induction (r = 0.27, p = 0.050), and with BIS at loss of consciousness (r = 0.32, p = 0.026).However, no correlation was seen between propofol requirement for induction with HR prior to induction (r = 0.13, p = 0.37). Anxious patients were unable to sleep well pre-operatively (p = 0.009). Conclusion: Preoperative state of anxiety does not influence propofol requirement for induction of anesthesia.

Publication Details

Page(s) 419-423

DOI DOI not available

Published Journal: Anaesthesia, Pain and Intensive Care, Volume: 22, Issue: 4, Year: 2018

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Keywords

Induction of anesthesia

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