Quality Assessment and Dissolution Profile Comparison Studies on Naproxen Tablets available in Karachi.

Fatima Qamar; Samina Alam; Safila Naveed; Huma Ali

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Quality Assessment and Dissolution Profile Comparison Studies on Naproxen Tablets available in Karachi.

Author(s)

Fatima Qamar Faculty of Pharmacy, Jinnah University for Women, Karachi, Pakistan

Samina Alam Faculty of Pharmacy, Jinnah University for Women, Karachi, Pakistan

Safila Naveed Faculty of Pharmacy, Jinnah University for Women, Karachi, Pakistan

Huma Ali Faculty of Pharmacy, Jinnah University for Women, Karachi, Pakistan

Abstract

Background: Naproxen, an NSAID, works by dropping down the hormones that cause inflammation as well as pain in the body. Naproxen is prescribed for the treatment of pain and inflammation, indicated for the conditions such as arthritis, spondylitis, ankylosing and tendinitis. Objective: The aim of this study is to compare six different brands of Naproxen Sodium. Methodology: Quality control parameters: weight variation test, thickness testing, hardness test, friability, disintegration and dissolution test were carried. Result: Result revealed that all the six brands comply within limits for hardness, weight variation, thickness, friability, disintegration test. Disintegration time for all brands was within 15 minutes complying with the USP commendation. Conclusion: The present findings suggest that all the brands meet the specification for quality control analysis. All the brands were best fitted with weibull model at pH 7.4.

Publication Details

Page(s) 32-35

DOI DOI not available

Published Journal: RADS Journal of Pharmacy & Pharmaceutical Sciences, Volume: 5, Issue: 2, Year: 2017

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Keywords

model independent, model dependent method, naproxen

References

JohnsonES,RatcliffeDM,WilkinsonM., 1985.Naproxen sodium in the treatment of migraine,Cephalalgia 5 5 -10

SancesG,MartignoniE,FioroniL,BlandiniF,FacchinettiF,NappiG, 1990.Naproxen sodium in menstrual migraine prophylaxis: a double‐blind placebo controlled study,Headache: The Journal of Head and Face Pain 30 705 -9

CsapoAI,PulkkinenMO,HenzlMR, 1977.The effect of naproxen-sodium on the intrauterine pressure and menstrual pain of dysmenorrheic patients,Prostaglandins 13 193 -9

SupraptoK,Reed S, 1984.Naproxen sodium for pain relief in first-trimester abortion,Am J Obstet Gynecol 150 1000 -

CaponeML,TacconelliS,SciulliMG,AnzellottiP,Di FrancescoL,MerciaroG,Di GregorioP,PatrignaniP, 2007.Human pharmacology of naproxen sodium,J Pharmacol Exp Ther 322 453 -60

SegreEJ, .,J Suppl ) 222 -5

SeveliusH,RunkelR,SegreE,BloomfieldSS, 1980.Bioavailability of naproxen sodium and its relationship to clinical analgesic effects,Br J Clin Pharmacol 10 259 -63

TripathiKD, 2013.Essentials of medical pharmacology,JP Medical Ltd -

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