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Antibacterial Potential Assessment of Schiff Bases Derived from 1-aminoanthracene-9, 10-dione.
Author(s)
Ghulam Fareed Pharmaceutical Research Centre, PCSIR Laboratories Complex, Karachi, Pakistan
Fouzia Khan Department of Microbiology, University of Karachi, Karachi, Pakistan
Nazia Faree Department of Chemistry, Federal Urdu University of Art, Sciences and Technology (FUUAST), Gulshan-e-Iqbal Campus, Karachi, Pakistan
Shahana Urooj Kazmi Department of Microbiology, University of Karachi, Karachi, Pakistan
Abstract
A variety of Schiff bases 1-17 of 1-aminoanthracene-9, 10-dione were synthesized using a reported catalytic method and evaluated for their antibacterial potential against Staphylococcus aureus multidrug resistant (MDR), Escherichia coli (MDR), Klebsiella species (MDR), Salmonella typhimurium (MDR), Pseudomonas aeruginosa (MDR), Escherichia coli ATCC-8739, Staphylococcus aureus ATCC25923, Staphylococcus aureus, Escherichia coli, Klebsiella species and Pseudomonas aeruginosa. Compounds 2, 3, 4, 13 and 14 were found to be potent against (MDR) bacterial strains when compared with the cefotaxime standard, however compound 8 exhibited good activities against S. aureus and Klebsiella species. Compounds 2 and 15 were found to be good to moderately active against P. aeruginosa and compounds 4 and 15 demonstrated moderate activity against S. aureus. All the remaining compounds except 11 and 17 showed weak antimicrobial activity against non-MDR strains of bacterial isolates.
Publication Details
Page(s) 15-18
DOI DOI not available
Published Journal: Pakistan Journal of Scientific and Industrial Research (Series A: Physical Sciences), Volume: 61, Issue: 1, Year: 2018
Keywords
Keywords are not available for this article.
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