Objective: To evaluate the correlation between burnout, self-esteem and quality of life among nurses. Study Design: Analytical, cross-sectional study. Place and Duration of Study: Sakarya Training and Research Hospital, Turkey, in 2013. Methodology: The sample was made-up of 131 volunteering nurses after obtainnig informed written consent from the participants, ethical committee, and corresponding institutions. Data were collected by personal information form (21 questions), Maslach Burnout Inventory (MBI-22 items), Rosenberg Self-Esteem Scale (RSES-10 items), Professional Quality Of Life Scale (ProQOL-30 items). Results: The scales were analysed in terms of internal consistency. Cronbach Alpha coefficients were determined as reliable for our sample. MBI 3 subscale total scores of the participant nurses were low for emotional exhaustion and depersonalization, high for personal accomplishment. Total score from RSES was 15.32 ±3.70. Total scores from 3 subscales of ProQOL were 29.78 ±9.02 for compassion satisfaction, 24.65 ±5.75 for burnout, and 15.12 ±6.54 for compassion fatigue. Conclusion: In this study, it was detected that burnout in nurses affected compassion satisfaction and individual success negatively.