A new method for the determination of isoniazid (isonicotinic acid hydrazide) by the Weisz ring-oven technique. | Pakistan Journal of Scientific and Industrial Research 1987

Author(s)

M. Hanif Pakistan Council of Scientific and Industrial Research, PCSIR Laboratories, Lahore, Pakistan

Sumra Naeem Pakistan Council of Scientific and Industrial Research, PCSIR Laboratories, Lahore, Pakistan

Haider Ali Pharmacy Department, Punjab University, Lahore, Pakistan

Shaukat Ali F. C. Government College, Lahore, Pakistan

Abstract

A new method has been described for the determination of isonicotinic acid hydrazide (isoniazid) making use of its reaction with ceric sulphate to give a yellow coloured end-product. Interferences by aspirin, paracetamol and caffeine on this determination have also been studied using the Weisz ring-oven technique. It has been observed that isonicotinic acid hydrazide can be determined within the range of 250.0 ng to 30.0Oug with a maximum error of 9.20 % for 250.0 ng of the substance. It can also be determined in the presence of paracetamol, aspirin and caffeine individually and collectively. The method is well suited to the routine analysis of isoniazid because of its accuracy, sensitivity, precision and convenience.

Publication Details

Page(s) 331-333

DOI DOI not available

Published Journal: Pakistan Journal of Scientific and Industrial Research, Volume: 30, Issue: 5, Year: 1987

Keywords

Keywords are not available for this article.

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