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1-(2,4-Dihydroxyphenyl)-1-ethanone hydrazone derivatives as notable butyrylcholinesterase inhibitors.
Author(s)
Muhammad Athar Abbasi Department of Chemistry, Government College University, Lahore-54000, Pakistan
Sikander Khan Niazi Department of Chemistry, Government College University, Lahore-54000, Pakistan
Aziz-Ur-Rehman Department of Chemistry, Government College University, Lahore-54000, Pakistan
Sabahat Zahra Siddiqui Department of Chemistry, Government College University, Lahore-54000, Pakistan
Ghulam-Hussain Department of Chemistry, Government College University, Lahore-54000, Pakistan
Shahid Rasool Department of Chemistry, Government College University, Lahore-54000, Pakistan
Muhammad Ashraf Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur-63100, Pakistan
Jamil Rahman Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur-63100, Pakistan
Khalid Mohammed Khan HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
Abstract
Azomethine group of Schiff bases is known to express valuable biological activities. 1- (2, 4-Dihydroxyphenyl)-1-ethanone N`-substituted hydrazone derivatives, 4a-s, were synthesized in multistep. The starting material 2, 4-dihydroxyacetophenone (1) was stirred with hydrated hydrazine to yield 1-(2, 4-dihydroxyphenyl)-1-ethanone hydrazone (2) which was further reacted with (un)substituted benzaldehydes, 3a-s, to acquire the target molecules, 4a-s. Moreover, the synthesized derivatives 4a-s was characterized via IR, EI-MS, 1H-NMR and 13C-NMR spectral techniques. Most of the compounds were found to be valuable inhibitors of butyrylcholinesterase enzyme.
Publication Details
Page(s) 106-114
DOI DOI not available
Published Journal: Journal of Chemical Society of Pakistan, Volume: 38, Issue: 1, Year: 2016
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