5-Arylidene N,N-dimethylbarbiturates as urease inhibitors. | Journal of Chemical Society of Pakistan 2014

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5-Arylidene N,N-dimethylbarbiturates as urease inhibitors.

Author(s)

Khalid Mohammed Khan HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan

Momin Khan HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan;Department of Chemistry, Abdul Wali Khan University, Mardan, Pakistan

Ajmal Khan HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan

Shahnaz Perveen PCSIR Laboratories Complex Karachi, Shahrah-e-Dr. Salimuzzaman Siddiqui, Karachi, Pakistan

Farzana Naz HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan

M. Iqbal Choudhary HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan

Abstract

Earlier 5-arylidene N,N-dimethylbarbiturates 1-24 were reported by our group as novel antioxidant, nevertheless, urease inhibitory activity of these compounds has not been investigated at all. In the present study, compounds 1-24 were synthesized by the reaction of N,N-dimethylbarbituric acid with different aromatic aldehydes, and screened for their in vitro urease inhibitory effects. Compound 7, was found to be most active urease inhibitor in the series. Nonetheless, compounds 11, 12, and 19 were also active against urease enzyme.

Publication Details

Page(s) 524-527

DOI DOI not available

Published Journal: Journal of Chemical Society of Pakistan, Volume: 36, Issue: 3, Year: 2014

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