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The prevalence of Epstein-Barr virus infection in head and neck non-Hodgkin`s lymphomas in Khorasan, northeast of Iran.
Author(s)
Reza Zare Mahmood Abadi Department of Oral & Maxillofacial Pathology, Dental Research Center, Faculty of Dentistry, Iran
Noorieh Sharifi Sistani Department of Clinico Anatomical Pathology, Quaem Hospital, Iran
Nooshin Mohtasham Department of Oral & Maxillofacial Pathology, Dental Research Center, Faculty of Dentistry, Iran
Kambiz Kamyab Hesari Department of Dermatopathology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran
Tooraj Vaezi Department of Oral & Maxillofacial Pathology, Dental Research Center, Faculty of Dentistry, Iran
Mahdi Pazouki Department of Oral & Maxillofacial Pathology, Dental Research Center, Faculty of Dentistry, Iran
Mohammad Taghi Shakeri Department of Community Medicine, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract
Objectives: To investigate the frequency and possible role of Epstein-Barr virus infection in non-Hodgkin`s lymphomas of the oral cavity and maxillofacial region in Khorasan (Northeast of Iran). Methods: The cross-sectional retrospective study assessed the frequency of Epstein-Barr virus infection in nonimmunosuppressed non-Hodgkin`s lymphoma cases of the oral cavity and maxillofacial region. Formalin-fixed, paraffin-embedded tissue sections from 34 cases of head and neck non-Hodgkin`s lymphoma (17 low-grade B-cell lymphoma, 14 diffuse large B-cell lymphoma, and 3 peripheral T cell lymphoma) were selected as a case group, and 10 normal lymph node sections were considered as a control group. Polymerase chain reaction was used to detect the EBV-DNA in tissue specimens. SPSS 16 was used for statistical analysis of the data. Results: EBV-DNA was detected in 26.5% of NHL samples. Among NHLs, Epstein-Barr virus was found to be positive in 50% cases with diffuse large B-cell lymphoma and 11.8% of low grade B-cell lymphomas. Epstein-Barr virus was not detected in any cases of peripheral T-cell lymphoma. Conclusion: Although it seems that Epstein-Barr virus appears to be an etiological factor in some subtypes of non- Hodgkin`s lymphomas, especially in diffuse large B-cell lymphoma, more researches should be done to investigate the relationship between Epstein-Barr virus infection and head and neck non-Hodgkin`s lymphomas.
Publication Details
Page(s) 882-887
DOI DOI not available
Published Journal: Journal of Pakistan Medical Association, Volume: 63, Issue: 7, Year: 2013
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