Nanodevices and biomolecules have incredibly strong correspondence in terms of size and physical properties. In this review, three major types of nanodevices, namely cantilevers, nanowires and carbon nanotubes, have been discussed and how they have resulted in new sensor designs or helped push the limits of detection in existing schemes. After brief overview of each type and the ways it could be used in biosensing, recent research efforts are presented to emphasise the challenges and achievements in that particular category.