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25-Hydroxyvitamin D is closely related with the function of the pancreatic islet ß cells.
Author(s)
Jingjing Guo Department of Endocrinology, Jinan Central Hospital Affiliated to Shandong University, Jinan, P R China
Zhengda Xiao Department of Endocrinology, Jinan Central Hospital Affiliated to Shandong University, Jinan, P R China
Xia Xue Department of Endocrinology, Jinan Central Hospital Affiliated to Shandong University, Jinan, P R China
Xin Liu Department of Endocrinology, Jinan Central Hospital Affiliated to Shandong University, Jinan, P R China
Yong Lu Department of Endocrinology, Jinan Central Hospital Affiliated to Shandong University, Jinan, P R China
Xiao Yin Department of Endocrinology, Jinan Central Hospital Affiliated to Shandong University, Jinan, P R China
Kun Ma Department of Endocrinology, Jinan Central Hospital Affiliated to Shandong University, Jinan, P R China
Abstract
Objectives: This study is to investigate the relationship between 25-Hydroxyvitamin D (25-OH-D) and pancreatic islet β cell function under different glucose tolerance statuses in China. Methodology: Totally, 180 patients with type 2 diabetes mellitus (DM group), 178 patients with impaired fasting glucose/impaired glucose tolerance (IFG/IGT group), and 160 normal control subjects (NGT group) were included to measure their body parameters and biochemical parameters. In oral glucose tolerance test, fasting serum 25-OH-D was assessed by the enzyme-linked immunosorbent assay (ELISA). Homeostasis model assessment for insulin resistance (Homa-IR), insulin acuity index (IAI), β-cell function index (Homa- BCF) as well as secretion index (IS) were determined. Results: The levels of 25-OH-D, IAI and Homa-BCF in the DM group and IFG/IGT group were significantly lower than that in NGT group (P
Publication Details
Page(s) 809-813
DOI DOI not available
Published Journal: Pakistan Journal of Medical Sciences, Volume: 29, Issue: 3, Year: 2013
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