The present study was conducted for the analysis and comparison of selected residual antibiotics in broiler chicken available in local market. The broiler samples included muscle, kidney and liver. The quinolones included in this study were, oxolinic acid, nalidixic acid, flumequine, enrofloxacin, norfloxacin and ciprofloxacin. An assessment of variation of these analytes (residues) in these samples was made. The intertissue/organ comparison within each analytical technique and intermethod comparison of results obtained by HPLC, UV spectroscopy and ion association complex techniques were made. TLC was used to separate and identify the quinolone residues. Infrared (IR) was also used for identification of the residues. HPLC with ODS column and UV detector and UV/ visible spectroscopy were used for quantification of the residues. Oxolinic acid, nalidixic acid and norfloliacin residues were absent in all the samples. The "ciprofloxacin-brilliant blue G" ion association complex was used for ciprofloxacin determination using ion association complex technique. Good compatibility of the spectrophotometric results was found with those of high pressure liquid chromatography.