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Butyrylcholinesterase inhibitory lignans from sarcostemma viminale.
Author(s)
Viqar Uddin Ahmad HEJ Research Institute of Chemistry International Center for Chemical Sciences University of Karachi, Karachi, Pakistan
Muhammad Zubaira HEJ Research Institute of Chemistry International Center for Chemical Sciences University of Karachi, Karachi, Pakistan
Muhammad Athar Abbasia HEJ Research Institute of Chemistry International Center for Chemical Sciences University of Karachi, Karachi, Pakistan
Farzana Kousara HEJ Research Institute of Chemistry International Center for Chemical Sciences University of Karachi, Karachi, Pakistan
Sarfraz A. Nawaza HEJ Research Institute of Chemistry International Center for Chemical Sciences University of Karachi, Karachi, Pakistan
M. Iqbal Choudhary HEJ Research Institute of Chemistry International Center for Chemical Sciences University of Karachi, Karachi, Pakistan
Syed Raziullah Hussaini Department of Chemistry, University of Kentucky, Lexington, KY 40506 USA
Abstract
The investigation of the chemical constituents of Sarcostemma viminale led to the isolation of two lignans, pinoresinol (1) and 9α-hydroxypinoresinol (2), which are reported for the first time from this species alongwith β -sitosterol (3), β-amyrin (4), lupeol (5), oleanolic acid (6) and ursolic acid (7). The structures of the these compounds were determined by 1D and 2D- homonuclear and heteronuclear NMR spectroscopy, chemical evidences, and by comparison with the published data of these compounds. The pinoresinol 1 and 9α-hydroxypinoresinol 2 displayed in vitro inhibitory activity against butyrylcholinesterase (BChE) enzyme with IC50 value of (15.0 ± 0.1) and (275.1 ± 2.4) µM respectively.
Publication Details
Page(s) 167-171
DOI DOI not available
Published Journal: Proceedings of Pakistan Academy of Sciences, Volume: 42, Issue: 3, Year: 2005
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