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Benzoylsalireposide an antioxidant, lipoxygenase and chymotrypsin inhibitor.
Author(s)
Muhammad Athar Abbasi HEJ Research Institute of Chemisty, International Center for Chemical Sciences, University of Karachi, Karachi, Pakistan
Viqar Uddin Ahmad HEJ Research Institute of Chemisty, International Center for Chemical Sciences, University of Karachi, Karachi, Pakistan
Muhammad Zubair HEJ Research Institute of Chemisty, International Center for Chemical Sciences, University of Karachi, Karachi, Pakistan
Muhammad Abid Rashid HEJ Research Institute of Chemisty, International Center for Chemical Sciences, University of Karachi, Karachi, Pakistan
Umar Farooq HEJ Research Institute of Chemisty, International Center for Chemical Sciences, University of Karachi, Karachi, Pakistan
Sarfraz A. Nawaz HEJ Research Institute of Chemisty, International Center for Chemical Sciences, University of Karachi, Karachi, Pakistan
Muhammad Arif Lodhi HEJ Research Institute of Chemisty, International Center for Chemical Sciences, University of Karachi, Karachi, Pakistan
Talat Makhmoor HEJ Research Institute of Chemisty, International Center for Chemical Sciences, University of Karachi, Karachi, Pakistan
M. Iqbal Choudhary HEJ Research Institute of Chemisty, International Center for Chemical Sciences, University of Karachi, Karachi, Pakistan
Attaur Rahman HEJ Research Institute of Chemisty, International Center for Chemical Sciences, University of Karachi, Karachi, Pakistan
Abstract
Two phenolic glycosides, benzoylsalireposide (1) and salireposide (2) were isolated from Symplocos racemosa Roxb, which showed DPPH radical scavenging activity, with the IC50 values of 773 ± 11.83 µM and 757 ± 0.374 µM respectively. In addition to this, compound 1 also displayed in vitro inhibitory potential against lipoxygenase and chymotrypsin in a concentration-dependent fashion with the IC50 values of 75.1 ± 0.5 µM and 65.07 ± 0.10 µM respectively, while 2 was inactive against these enzymes.
Publication Details
Page(s) 121-124
DOI DOI not available
Published Journal: Proceedings of Pakistan Academy of Sciences, Volume: 42, Issue: 2, Year: 2005
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