Indian crested porcupine, Hystrix indica, in Pakistan, is a pest of economic importance in forestry and agricultural systems. A simple, safe, effective and environment-friendly delivery system for carbon monoxide fumigation of porcupine dens, using two- ingredient cartridge, is described and evaluated. Employing this system, cartridges of various weights were tested in different habitats and soil conditions. The test results indicated 100 percent reduction in active porcupine dens with the usage of 250, 350, 375g cartridges in porous sandy, clay loam and silt loam soils having varied moisture contents. The system is highly suitable for effectively using two–ingredient cartridge for fumigating the dens of foxes, jackals, coyotes, dingoes and denning porcupines.