8-hydroxydeoxyguanosine levels, periodontitis in smoker and non-smoker: A pilot study. | Journal of Pakistan Dental Association 2006

Author(s)

Balwant Rai Government Dental College, Pt. bhagwat Dayal Sharma, Post Graduate Institute of Medical Science, rohtak, Haryana, India

S. C. Anand Government Dental College, Pt. bhagwat Dayal Sharma, Post Graduate Institute of Medical Science, rohtak, Haryana, India

Rajnish Jain Dental Wing Maulana Azad Medical College, New Delhi, India

Simmi Kharb Pt. Bhagwat Dayal Sharma, Post Graduate Institute of Medical Science, Rohtak, Haryana, India

Abstract

To determine the association between levels of a marker of oxidative stress, 8-hydroxydeoxyguanosine (S-OHdG), in saliva and presence ofperiodontitis in smokers and non-smokers. Forty subject samples, as healthy control (n=16), periodontitis in smokers (n=11) and periodontitis in non-smokers (n=13) were recruited for the study. The 8-OHdG was analyzed in the saliva of smoking and non-smoking patients of periodontitis and healthy control. Salivary levels of 8-OHdG were significantly higher in subject with periodontitis who smoked as compared to non-smoker (6.82 + 0.18 ng/ml and 4.83 + 0.16 ng/ml). Thus, measurement of 8-OHdG may prove to be useful in identifying periodontal disease and risk of tooth loss.

Publication Details

Page(s) 89-90

DOI DOI not available

Published Journal: Journal of Pakistan Dental Association, Volume: 15, Issue: 2, Year: 2006

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