a-glucosidase and chymotrypsin inhibiting lignans from Commiphora mukul. | Proceedings of Pakistan Academy of Sciences 2005

Author(s)

Muhammad Athar Abbasi HEJ Research Institute of Chemistry, International Center for Chemical Sciences University of Karachi, Pakistan

Viqar Uddin Ahmad HEJ Research Institute of Chemistry, International Center for Chemical Sciences University of Karachi, Pakistan

Muhammad Zubair HEJ Research Institute of Chemistry, International Center for Chemical Sciences University of Karachi, Pakistan

Shamsun Nahar Khan HEJ Research Institute of Chemistry, International Center for Chemical Sciences University of Karachi, Pakistan

Muhammad Arif Lodhi HEJ Research Institute of Chemistry, International Center for Chemical Sciences University of Karachi, Pakistan

M. Iqbal Choudhary HEJ Research Institute of Chemistry, International Center for Chemical Sciences University of Karachi, Pakistan

Abstract

Phytochemical investigation of the whole plant of Commiphora inukui Engl. resulted in the isolation of two lignans, epiexcelsin (1) and 5`-demethoxyepiexcelsin (2) which are reported for the first time from this species. The structure elucidation of the isolated compounds was based on 1 D and 2DNMR analysis and by the comparison with the published data. The lignans 1 and 2 showed significant inhibitory activity against α-glucosidase with the IC50 of 59.8±3.63455 µM and 75.2±8.1616 µM respectively. They also showed weak inhibitory potential against chymotrypsin with the IC50 of 110±0.025 µM and 649±0.013 µM respectively.

Publication Details

Page(s) 23-26

DOI DOI not available

Published Journal: Proceedings of Pakistan Academy of Sciences, Volume: 42, Issue: 1, Year: 2005

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