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3EFFECT OF G.13700A>G AND G.25783C>T IN PIT-1 GENE ON GROWTH TRAITS OF DUROC, LANDRACE, YORKSHIRE PIG
Author(s)
X. Dong Faculty of Animal Science and Technology, Yunnan Agricultural University, Fengyuan Road 452, Panlong, Kunming 650201, Yunnan, China
Z. Liu Faculty of Animal Science and Technology, Yunnan Agricultural University, Fengyuan Road 452, Panlong, Kunming 650201, Yunnan, China
X. Wang Faculty of Animal Science and Technology, Yunnan Agricultural University, Fengyuan Road 452, Panlong, Kunming 650201, Yunnan, China
Q. Chen Faculty of Animal Science and Technology, Yunnan Agricultural University, Fengyuan Road 452, Panlong, Kunming 650201, Yunnan, China
G. Bai Dehong Animal Husbandry Station, Dehong 679399, Yunnan, China
G. Lan Faculty of Animal Science and Technology, Yunnan Agricultural University, Fengyuan Road 452, Panlong, Kunming 650201, Yunnan, China
Q. Wang Faculty of Animal Science and Technology, Yunnan Agricultural University, Fengyuan Road 452, Panlong, Kunming 650201, Yunnan, China
M. Li Faculty of Animal Science and Technology, Yunnan Agricultural University, Fengyuan Road 452, Panlong, Kunming 650201, Yunnan, China
D. Yan Faculty of Animal Science and Technology, Yunnan Agricultural University, Fengyuan Road 452, Panlong, Kunming 650201, Yunnan, China
S. Lu Faculty of Animal Science and Technology, Yunnan Agricultural University, Fengyuan Road 452, Panlong, Kunming 650201, Yunnan, China
Abstract
Pituitary specific transcription factor-1 (Pit-1) gene is responsible for pituitary development and growth hormone expression, which is considered a pivotal candidate gene for growth in pig. This study aims to detect novel single nucleotide polymorphisms (SNPs) in porcine Pit-1 gene, investigate its effect on growth traits in the Duroc, Landrace and Yorkshire pigs. Two novel polymorphisms were detected, one located in the intron 2 (g. 13700 A>G) and another located in exon 4 (g.25783 C>T) which caused an amino acid change from threonine to methionine (Thr36Met). At g.13700 A>G site, the frequency of A allele was higher than G allele in Duroc, Landrace and Yorkshire. At the g.25783 C>T site, it was remarkable differences in allelic frequencies and genotypic frequencies among the three pig breeds. This study demonstrated the significant genotype effect of Pit-1 on body weights at 70 d, age when reached 30kg, 50kg, 100kg and average daily gain from 30kg to 100kg. According to our results, the novel Pit-1 polymorphisms may be useful in pig selection as molecular markers and required in future studies.
Publication Details
Page(s) 1286-1291
DOI 10.36899/JAPS.2023.6.0668
Published Journal: Journal of Animal and Plant sciences, Volume: 33, Issue: 6, Year: 2023
Keywords
growth traits polymorphisms Pit1 Pig
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