Histone HI sub-types in mouse: Interplay between phosphorylation and O-glycosylation. | Pakistan Journal of Zoology 2007

Author(s)

Ishtiaq Ahmad Institute of Molecular Sciences & Bioinformatics, Lahore, Pakistan

Waqar Ahmad Institute of Molecular Sciences & Bioinformatics, Lahore, Pakistan

Evelyne-Walker-Nasir Institute of Molecular Sciences & Bioinformatics, Lahore, Pakistan

M. Saleem Department of Botany, University of Punjab, Lahore, Pakistan

Abdul R. Shakoori School of Biological Sciences, University of the Pun jab, Lahore, Pakistan

Nasir-Ud-Din HEJ Research Institute of Chemistry, University of Karachi, Karachi and Institute of Management Sciences, Geneva, Switzerland

Abstract

Linker histone Hl belongs to the family of proteins that are involved in organizing eukaryotic DNA into a compact structure. Many types of linker histone HI are found in mammals; and the subtypes are cell specific and their amount in different types of cells varies according to the cell functions. Post-translational modifications occur on different amino acids in each subtype of linker histone III that induce conformational changes and consequently allow linker histone H I to interact with chromatin at different stages during the cell cycle. This results in the regulation of transcription and gene expression. In this study it is proposed that O-glycosylation of linker histone III promotes condensation of chromatin, while, as it is known, phosphorylation of linker histone 1-11 activates transcription and gene regulation by decondensation of chromatin. Interplay between phosphorylation and O-/3GIcNAc modification on Ser and Thr residues in each subtype of linker histone H I during the cell cycle may result in diverse functional regulation of proteins. This in silico study describes the potential phosphorylation, glycosylation and their possible interplay sites on conserved Ser/Thr residues in various subtypes of linker histone III in Mus, musculus.

Publication Details

Page(s) 245-257

DOI DOI not available

Published Journal: Pakistan Journal of Zoology, Volume: 39, Issue: 4, Year: 2007

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