Ticks infestation and piroplasmosis are serious problems of domestic cattle. The present study was conducted to find out the prevalent species of ticks and the piroplasms transmitted by these ticks. The effect of ticks and blood parasites on various blood parameters was also studied. The parameters included: TEC count, TLC count, haemoglobin (Hb) estimation, erythrocytic sedimentation rate (ESR) and differential leukocytic count (DLC). The study was conducted from June to August 2001. A total of 80 cattle (40 local nondescript cattle and 40 crossbred) were selected. Each type was divided into four groups A, B, C and D. The cattle of group-A were free from any infestation/infection. The animals of group B were only tick infested. Animals of group-C were only piroplasm infected and the animals of group-D were infested with ticks and the piroplasms infected. Each group from both the genetic groups consisted of 10 animals. Haemotological examination revealed a significant decrease (f