Diabetes is the major non-contagious, long-lasting epidemic disease caused by abnormal blood glucose levels resulting from the disablement in insulin action and secretion. The objective of the study is to estimate diabetes mellitus and risk factors of diabetes mellitus in the population of district Swabi, Khyber Pakhtunkhwa, Pakistan. A total of 150 blood samples are collected from March-July 2021. All diabetic patients are screened randomly using a spectrophotometer (Micro Lab 300). At the same time, data regarding subjective information, socioeconomic status, and behavioural risk factors are collected by personal interviews, which are further statistically analysed. Results show that the frequency distribution of diabetes is n= 107 (71.3%) while n= 43 (28.7%) of the total n=150 are normal. Mean±sd of the data is 1.29±0.45. There is a significant association between diabetes mellitus and hypertension (n= 95, 63%, Cl 95%, and P-value 0.041). Hyperglycaemia is n= 109 (72.7% and P-value 0.00), and anxiety/depression is n= 95 (63% and P-value 0.004). Gender, age, education, and smoking (p-value > 0.05) are nonsignificant risk factors for diabetes. The findings show a significant association among diabetes mellitus, hypertension, hyperglycaemia, and depression.