A comparison of the clinical features of molar pregnancy in adolescents and adults | Pakistan Journal of Medical Sciences 2024

Author(s)

Mehmet Ozer Dept. of Obstetrics & Gynaecology, University of Health Sciences, Tepecik Training and Research Hospital, Izmir, Turkey.

Pınar Tugce Ozer Dept. of Obstetrics & Gynecology, Izmir Economy University, School of Medicine, Medical Point Hospital, Izmir, Turkey.

Ibrahim Karaca Dept. of Obstetrics & Gynaecology, Izmir Bakircay University, Cigli Education and Research Hospital, Izmir, Turkey.

Suna Karaca Dept. of Obstetrics & Gynaecology, University of Health Sciences, Tepecik Training and Research Hospital, Izmir, Turkey.

Alper Ileri Dept. of Obstetrics & Gynaecology, University of Health Sciences, Tepecik Training and Research Hospital, Izmir, Turkey.

Adnan Budak Dept. of Obstetrics & Gynaecology, University of Health Sciences, Tepecik Training and Research Hospital, Izmir, Turkey.

Abstract

Objective: To compare the age-specific clinical features of molar pregnancy and to describe the risk factors associated with this situation. Method: This retrospective case-control study was conducted at the Department of Obstetrics and Gynecology. Tepecik Education and Research Hospital, Izmir, Turkey. The participants included both adolescents (= 19 years) and adults with histologically confirmed hydatidiform moles in our institution between January 2015 and January 2022. The interventions and main outcome measures of this study involved evaluating the clinical and ultrasonographic features, as well as the risk factors, associated with molar pregnancies in adolescents. Results: This study of 137 patients with molar pregnancy found that adults had a higher incidence of partial molar pregnancy (20 patients versus seven patients) and lower beta-hCG levels than adolescents (176.890.71 mIU/ml versus 253.734.47 mIU/ml). Adolescents had a higher likelihood of hyperthyroidism (25.4% versus 9.2%). bleeding on admission (4.2% versus 1.51%),. longer hospital stays (5.44 ± 2.73 days versus 3.59 ± 3.08 days). Higher rates of uterine enlargement and postoperative bleeding (15.5% versus 1.5%). Adolescents also required more analgesia (97% versus 89.4%). Conclusions: Adolescents with Gestational trophoblastic diseases (GTD) may present with more severe symptoms compared to adults, which can lead to delayed diagnosis and treatment. Further research is needed to better understand the underlying mechanisms and risk factors for GTDs in this population. Increased awareness and education can help improve recognition and management of GTDs in adolescents and improve their overall health outcomes.

Publication Details

Page(s) 846-850

DOI 10.12669/pjms.40.5.8383

Published Journal: Pakistan Journal of Medical Sciences, Volume: 40, Issue: 5, Year: 2024

Keywords

Hydatidiform mole Vaginal bleeding Gestational trophoblastic diseases Visual analogue scores

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