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A Comprehensive Study on Bioengineering Strategies of Osseous Reconstruction by Using Autogenous Bone Graft with Osteogenic Biologics for Radial Diaphyseal Defect Repair
Author(s)
Naveed Hussain Department of Veterinary Surgery, University of Veterinary and Animal Sciences Lahore, 54000, Pakistan
Muhammad Arif Khan Department of Veterinary Surgery, University of Veterinary and Animal Sciences Lahore, 54000, Pakistan
Asim Khalid Mahmood Department of Small Animal Clinical Sciences, University of Veterinary and Animal Sciences Lahore, 54000, Pakistan
Muhammad Yasin Tipu Department of Pathology, University of Veterinary and Animal Sciences Lahore, 54000, Pakistan
Mamoona Chaudhry Department of Epidemiology and Public Health, University of Veterinary and Animal Sciences Lahore, 54000, Pakistan
Hamad Bin Rashid Department of Veterinary Surgery, University of Veterinary and Animal Sciences Lahore, 54000, Pakistan
Haroon Akbar Department of Epidemiology and Public Health, University of Veterinary and Animal Sciences Lahore, 54000, Pakistan
Abdul Aziz Department of Veterinary Clinical Sciences, University of Poonch Rawlakot, 12350, Pakistan
Abstract
Complex fracture reconstruction, malunion, delayed and nonunion are challenging problems often require special attention. Autogenous bone graft for osseous healing has been considered gold standard for decades. It contains viable osteoprogenitor cells, cytokines and growth factors with appropriate tissue matrix resulting in osteogenesis, osteoinduction and osteoconduction. Orthobiologics are biological materials used to augment bone and soft tissue cure, with multifactorial effects. In our study, three orthobiologics i.e., Bone Marrow Aspirate (BMA), Platelet Rich Plasma (PRP) and Decellularized Fish Scale (DFS) were used in conjunction to autogenous bone graft. Objective was to transplant as many cells as possible with osteogenic potential along with the graft. These three regimens were evaluated in terms of clinical vital parameters, hematology, serum analysis, bone biomarkers, mechanical assessment, radiographic evaluation and histomorphometry. We concluded that Bone-BMA combination showed best results in fracture healing and bone remodeling while Bone-PRP combination was below par than Bone-BMA but was superior to Bone-DFS combination. More clinical research may be required before widespread use of these regimens. Furthermore, it is paramount that veterinary orthopedic surgeons must have contemporary knowledge regarding autogenous grafts and orthobiologics, so they can utilize them correctly.
Publication Details
Page(s) 1671-1680
DOI 10.17582/journal.pjz/20221012181035
Published Journal: Pakistan Journal of Zoology, Volume: 56, Issue: 4, Year: 2024
Keywords
Platelet rich plasma Bone marrow aspirate Fracture Healing Autogenous bone graft Fish scale
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