An Estimate of Protective Immunity against SARS-CoV2: Comparison of Diferent Vaccine Types | Proceedings of the Pakistan Academy of Sciences: B. Life and Environmental Sciences 2023

Author(s)

Waseem Iqbal Department of Pathology, Mardan Medical Complex Teaching Hospital, Mardan, Pakistan; Department of Medical Lab Technology, The University of Haripur, Haripur, Pakistan

Ikram Ullah Department of Medical Lab Technology, The University of Haripur,Haripur,Pakistan

Uroosa Irum Department of Microbiology, Abdul Wali Khan University Mardan,,Pakistan

Saima Siddiqi Department of Rare and Infectious Disease, Institute of Biomedical and Genetic Engineering, Islamabad, Pakistan

Khalid Mahmood Khan University of Agriculture,Faisalabad,Pakistan

Abstract

Several types of vaccines have been approved to prevent SARS-CoV-2 infection. Few studies are conducted on the eficacy of COVID-19 vaccines. Vaccination is important to eliminate and fight SARS-CoV-2 infection and several vaccines have been approved. This study aimed to assess the incidence density of COVID-19 infection among the community, estimate the efectiveness of diferent types of vaccines (inactivated virus, viral vector or mRNA) and eficiency of incomplete and complete vaccination. In this observational cross-sectional study, a total of 4924 specimens were received from 1st January 2022 to 2nd February 2022 for the detection of SARS-CoV-2. The patient's age, gender, and vaccination data were recorded and S, N, and ORF 1ab genes were amplified after RNA extraction through PCR. out of which 1034 (20.99 %) cases were positive. Among 1034 (20.99 %) positive cases, 418 and 616 patients were vaccinated and non-vaccinated respectively. The cases of SARS-CoV-2 in vaccinated patients were categorized into a sudden infection (= 10 days) and late infection (=10 days) after the incomplete and complete dose of vaccination. Vaccination provides partial protection against SARS-CoV-2 infection. This might be due to the low eficacy and inability to detect recent variations in the protein structure of the virus.

Publication Details

Page(s) 377-382

DOI 10.53560/PPASB(60-3)749

Published Journal: Proceedings of the Pakistan Academy of Sciences: B. Life and Environmental Sciences, Volume: 60, Issue: 3, Year: 2023

Keywords

SARSCoV2 Ct Value COVID19 Vaccine Types Vaccine Efectiveness

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