The relationship between prostatic volume and serum estrogen in obese versus non obese males with benign prostatic hyperplasia | BioSight 2023

Author(s)

Afsheen Khan Department of Anatomy, Shaheed Mohtarma Benazir Bhutto Medical College,Liyari, Karachi,Pakistan

Saif Ullah Shaikh Department of Physiology, Bahria University Health Sciences,Karachi campus,Pakistan

Naheed Khan Department of Anatomy, Dow Medical College. Dow University of Health Sciences,Karachi, Pakistan

Rabiya Ali Department of Physiology, Karachi Institute of Medical Sciences. National University of Medical Sciences, CMH. Malir Cantt,Karachi,Pakistan

Sundas Ahmad Department of Medical Education Rai Medical College Sargodha,,Pakistan

Abstract

Background: Old age, obesity and androgens are more vulnerable to prostatic disorders. Benign Prostatic Hyperplasia (BPH) is a common problem for adults. Objectives: To determine the morphological changes of prostate gland and effects of Estrogen levels in obese versus non-obese males with BPH. Methods: A cross sectional study was conducted on sixty patients in an emergency clinic of Dr. Ruth Pfau, Dow university of Health Sciences, Karachi from 17th May 2019 to 15th February 2020(IRB-1182/DUHS/approval/2019). All selected patients have BPH and assessed by Global prostate side effect score >7. Patients with BPH were divided into two groups obese and non-obese, as indicated by Body Mass Index (BMI) and waist circumference (WC). Group A (obese) had BMI = 25; WC = 90cm and group B (non-obese) had BMI < 25; WC < 90cm. Trans rectal ultrasound and estimation of serum Estrogen was performed to analyzed the length, width, diameter and volume of prostate. Results: The mean prostate volume was higher in the obese group 36.13±3.673ml while in non-obese group it was 31.21±6.771 ml, which was found to be statistically significant (p = 0.001). The mean Estrogen levels in obese group were 328.21±115.05pmol/l, while in non-obese group it was 309.72±73.62pmol/l (p=0.462). Significant positive correlation was observed (r = 0.279, p=0.031) between prostate volume and serum Estrogen levels in study participants. Conclusion: Obesity and serum Estrogen levels had significant effect on the prostate volume as compared to non-obese participants within same age group which showed significant moderate positive correlation with prostate volume in obesity.

Publication Details

Page(s) 89-94

DOI 10.46568/bios.v4i2-3.118

Published Journal: BioSight, Volume: 4, Issue: 2--3, Year: 2023

Keywords

Body mass index Obesity Benign prostatic hyperplasia Waist Circumference Transrectal ultrasonography Serum Estrogen

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