Background: Anti-tubercular drugs are known to causes hepatic injury, leading to stop the medical treatment by people globally. Ajwa data as herbal medicine may help in hepatic recovery. Objective: To find the precautionary of Ajwa date on hepatotoxicity induced by anti-tubercular drugs in rabbits. Study Design: Experimental study. Settings: Department of Pharmacology, Post Graduate Medical Institute, Lahore Pakistan. Duration: One year from June 2018-June 2019. Methods: Thirty rabbits were divided into five groups (A, B, C, D & E). Two groups (A, B) were on normal diet and drugs. Three groups (C, D & E) were on drug + Ajwa(seed/flesh) for 14 days. Hepatotoxicity was confirmed by liver enzymes (ALT & AST) and by histopathology of liver tissue. Results: Level of ALT and AST were in normal limits in all groups at the start of experiment. Significant hepatotoxicity was seen after 2 weeks of orally given INH and rifampicin in group B as compared to healthy control group A. Using of Ajwa date during the same period decreased the high levels of enzymes in groups C, D and E and brings liver function normal like healthy controls. Histological findings showed that after the administration of Ajwa, its flesh and powder, the changes of liver structure like degeneration, steatosis, necrosis etc. are relieved. Conclusion: Co-administration of Ajwa date along with its constituents are parallel and effective in reducing isoniazid and rifampicin induced hepatotoxicity.