The Role and Pathogenetic Mechanisms of Long Non- Coding RNAs in Liver Fibrosis | Archives of Pharmacy Practice 2023

Author(s)

Denis Sergeevich Shpakov Department of Hospital Therapy, Therapeutic Faculty of Stavropol State Medical University, Stavropol, Russia.

Marianna Evgenevna Romas Department of Therapy, Medical Faculty of Stavropol State Medical University, Stavropol, Russia

Alena Gochaevna Margieva Department of Therapy, Medical Faculty of North Ossetian State Medical Academy, Vladikavkaz, Republic of North Ossetia-Alania, Russia.

Milana Evgenievna Brovkina Department of Therapy, Medical Faculty of Stavropol State Medical University, Stavropol, Russia

Ellina Borisovna Khabieva Department of Therapy, Dental Faculty of North Ossetian State University named after K.L. Khetagurov, Vladikavkaz, Republic of North Ossetia-Alania, Russia.

Sofya Ruslanovna Mutalieva Department of Therapy, Pediatric Faculty of Stavropol State Medical University, Stavropol, Russia.

Abstract

Liver fibrosis is a serious disease characterized by the excessive formation of connective tissue in an organ with a predisposition to cirrhosis. Understanding the mechanisms underlying the development of liver fibrosis is an important step towards the development of new methods for the diagnosis and treatment of this disease. Long non-coding RNAs (lncRNAs) are a class of RNAs that have been shown to play an important role in the pathogenesis of liver fibrosis and may be potential targets for new therapeutic approaches. This article reviews the role and pathogenetic mechanisms of lncRNAs in liver fibrosis, studies related to the identification of these mechanisms, as well as the prospects for using lncRNAs as diagnostic markers and therapeutic targets. The identification and study of these lncRNAs may provide new opportunities for the development of innovative approaches to the diagnosis and treatment of liver fibrosis. Further research is needed to fully understand the molecular mechanisms associated with lncRNAs and liver fibrosis and to determine their potential as biomarkers and therapeutic targets.

Publication Details

Page(s) 7-9

DOI 10.51847/5YE2FxmN9M

Published Journal: Archives of Pharmacy Practice, Volume: 14, Issue: 3, Year: 2023

Keywords

Pathogenesis gene expression Liver fibrosis long noncoding RNAs lncRNAs

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