A case report of HLA-Cw6 discordances in monozygotic twins The role of epigenetic mechanism | Journal of Pakistan Association of Dermatologists 2023

Author(s)

Nuril Ilmi Department of Dermatology and Venereology, Faculty of Medicine, Hasanuddin University,Makassar, South Sulawesi,Indonesia

Faridha Ilyas Department of Dermatology and Venereology, Faculty of Medicine, Hasanuddin University,Makassar, South Sulawesi,Indonesia

Anni Adriani Department of Dermatology and Venereology, Faculty of Medicine, Hasanuddin University,Makassar, South Sulawesi,Indonesia

Khairuddin Djawad Department of Dermatology and Venereology, Faculty of Medicine, Hasanuddin University,Makassar, South Sulawesi,Indonesia

Abstract

Psoriasis is a systemic autoimmune disease influenced by genetic and environmental factors. The gene HLA-Cw6 is one of the most strongly associated proteins in psoriasis development. Recently, studies regarding monozygotic twins with psoriasis revealed that phenotype concordance among monozygotic twins was approximately 35-72%. We present a case of 15-year-old monozygotic twins female with psoriasis that exhibited difference in both onset and severity. HLA-Cw6 expression was negative in the twin that exhibited minimal cutaneous manifestation compared to the one with a more severe clinical presentation. We hypothesized that, epigenetic modification played an important role in phenotypic differences even though both patients theoretically have similar DNA sequences. This paper may merit further investigation regarding the nuanced interactions between genetics and the environment towards the clinical outcome of psoriasis patients.

Publication Details

Page(s) 791-795

DOI DOI not available

Published Journal: Journal of Pakistan Association of Dermatologists, Volume: 33, Issue: 2, Year: 2023

Keywords

Psoriasis Abstract Psoriasis Monozygotic twins Early onset HLACw6 eolgtDisease severity

References

References are not available for this document.

Citations

Citations are not available for this document.