Aim: Though standard laparoscopy has increasingly gained acceptance as the surgical therapy for ovarian cancer, decreasing laparoscopy sequence number remains a significant issue for bigger ovarian tumors. Thus, the goal of this review is to contrast the clinical results of solitary laparoscopy for eliminating large ovarian cysts (16 cm) to those of laparotomy and 3-port laparoscopy. Methods: Our current research included 96 individuals with large ovarian cysts (>16 cm) which had single-port, 3port, or else laparotomy. Patients' health records, perioperative surgical results, postoperatively score, and complications were all evaluated and discussed retrospectively. Our current research was conducted at Services Hospital Lahore from May 2020 to April 2021. Results: 1-port laparoscopy produced improved perioperative results and less postoperative discomfort compared to 3-port laparoscopy and laparotomy. The duration during process and waking up in the morning was significantly shorter in 1-port laparoscopy than in laparotomy and three-port laparoscopy (18.548.17 vs 28.428.58 vs 23.558.77, P0.02). The hospital admission was substantially lower in single-port laparoscopy set than in extra two sets (5.070.6 vs 6.472.64 vs 5.820.84, P0.002). Furthermore, single-port laparoscopy resulted in lower postoperative discomfort notches than laparotomy and 3-port laparoscopy. Conclusion: Single-port laparoscopy is indeed very secure and effective method for large ovarian cysts, only with benefits of the shorter surgery duration, less anticipated blood loss, a shorter hospital stays, a reduced spillage rate, and lesser postoperative discomfort.