Spices have always been predominant due to their culinary and medicinal usage. Among spices, Cinnamon is an important spice due to its medicinal and therapeutic potential throughout ancient times. It was known as the "holy anointing oil," a major ingredient used by Moses to bless his people. Scientific research provides solid evidence of cinnamon having antitumor, anti-depression, antihyperglycemic, anti-inflammatory, and anticarcinogenic potential. Depression is a commonly prevailing psychiatric illness that affects our mental health. It affects the optimum regulation of serotonin, a hormone responsible for mood elation. Cinnamon and its derivatives, such as transcinnamaldehyde (TCA), which is a COX-2 inhibitor, have been proven to suppress depression-like behaviors (tested on mice). TCA is a major component of cinnamon and influences the endocannabinoid (eCB) system positively. The cinnamon-containing compounds, such as proanthocyanidin, also helped to reduce lipopolysaccharide-induced depressive behavior. Various other compounds such as phenol turmerone, linalool, and eugenol all contribute to the reduction of neuroinflammation, which, in turn, decreases depressive attitudes. Furthermore, cinnamon reduces cholesterol levels to some extent, which has an association with depression and a certain relation to hormonal imbalance. Consequently, cinnamon can help in the elevation of mood and suppression of anxiety and depression.