The use of pesticides has played a significant role in pest control and improving crop yields. However, concerns have been raised about the indiscriminate use of pesticides in agricultural crops, particularly vegetables. The study was aimed to examine the knowledge and practices of farmers regarding pests and pesticide use in the Thatta district. Sixty small-scale male farmers willingly participated in the study. The literacy rate of the farmers varied, with 6 being illiterate, 25 having primary education, 13 having middle education, 9 having secondary education, and 7 being university graduates, including 2 agriculturists. The age distribution of the farmers revealed that 6 were between 20 to 30 years old, 11 were between 30 to 40 years old, and the majority were between 40 to 60 years old. The data indicated that farmers did not adhere to proper safety measures when applying pesticides. The study also found that the cost of pesticides was highest for vegetables, especially cauliflower, brinjal, okra, and tomatoes. Enhancing farmers' awareness of the environmental hazards associated with pesticides and promoting alternative pest management strategies, such as the use of bio-pesticides and integrated pest management (IPM), are essential for mitigating the adverse effects on the environment and human health.