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Antioxidative Role of Honey and L-Dopa against MPTP-induced Oxidative Stress in Adult Swiss Mice Model of Parkinson’s Disease
Author(s)
Sulaimon F.A Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin
Adeyemo E.A Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin
Yussuf R. A Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin
Emaye M.A Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin
Olaoye J.K Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin
Aina I.E Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin
Ashir F. A Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin
Jimoh H.B Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin
Ibiyeye R.Y Department of Public Health Sciences (Anatomy Unit), Faculty of Pure and Applied Sciences, Kwara State University, Malete
Imam A.L Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin
Biliaminu S. A Department of Chemical Pathology Faculty of Basic Clinical Sciences, College of Health Sciences, University of Ilorin, Ilorin
Shehu M Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin
Oyewole A.L Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilori
Ajao M.S Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin
Abstract
Oxidative stress is vital in the pathogenesis and progression of Parkinson’s disease (PD). 75% of dopaminergic (DA) neurons are already lost before the manifestation of the movement disorders. Moreover, one of the differential diagnoses of PD is its response to L-Dopa which does not prevent its progression. Hence, the need for neuroprotective therapy. Honey has been reported to be a radical scavenging gel and an enhancer of the antioxidant defence system. To investigate the antioxidative role of honey and L-Dopa against MPTP-induced oxidative stress.40 animals used for this study were divided into control and PD model groups of 20 animals each. Ten control animals received PBS, while the others received 1.5ml/kg body weight of honey and 80mg/ kg body weight of L-Dopa for 21 days. However, 10 of the PD model group were pretreated with HON and L-Dopa before PD induction. Behavioural studies were conducted two days after the induction, while the animals were euthanised seven days after. The result shows significantly (P=0.05) higher motor activities in the PD models pretreated with honey and L-Dopa. Furthermore, the pretreatment protected the midbrain against the gross neuronal damage and astrogliosis observed in the non-treated PD models. The expression of nuclear factor erythroid 2-related factor 2 (Nrf2) was also significantly upregulated (P=0.05) in the midbrain of the pretreated PD models. Pretreatment with honey and L-Dopa protected the DA neurons against oxidative stress via the mediation of the Nrf2 pathway.
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Published Journal: Abstract Book on 9th Annual Neuroscience Conference (ANC-23) August 12-13, 2023 , Volume: 0, Issue: 0, Year: 2023
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