Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide, contributing to a significant burden on healthcare systems. Coronary angioplasty (PCI) with stenting is a commonly performed procedure for CAD, has shown efficacy in reducing angina symptoms, improving myocardial perfusion, and preventing major adverse cardiac events. However, the impact of PCI on patients` mental health and overall wellbeing remains an important area of investigation. This study aimed to investigate the impact of PCI on the mental health and wellbeing of patients with CAD.This research utilized a prospective cohort design to investigate health-related quality of life and mental wellbeing in patients with CAD undergoing PCI. A total of 100 CAD patients scheduled for elective PCI were recruited from a cardiac center. Health-related quality of life and mental wellbeing were assessed at three time points: pre-procedure (baseline), 1 month post -PCI, and 6 months post-PCI. Validated instruments were used to measure these outcomes.The results showed significant improvements in psychological outcomes following PCI. Participants experienced a significant decrease in depression scores from baseline (M = 16.2, SD = 4.3) to 1 month (M = 12.8, SD = 3.9, p < 0.001) and 6 months (M = 11.6, SD = 4.1, p < 0.001) post-PCI. Similarly, anxiety scores significantly decreased from baseline (M = 34.7, SD = 6.1) to 1 month (M = 29.8, SD = 5.5, p < 0.001) and 6 months (M = 28.2, SD = 5.8, p < 0.001) post-PCI. Quality of life scores significantly improved from baseline (M = 65.4, SD = 8.7) to 1 month (M = 73.2, SD = 7.5, p < 0.001) and 6 months (M = 76.5, SD = 7.2, p < 0.001) post-PCI. Psychological wellbeing scores also significantly increased from baseline (M = 52.1, SD = 9.2) to 1 month (M = 57.8, SD = 8.4, p < 0.001) and 6 months (M = 60.3, SD = 8.1, p < 0.001) post-PCI. Angioplasty or PCI has a significant positive impact on the mental health and wellbeing of patients with CAD, as evidenced by improvements in depression, anxiety, quality of life, and psychological wellbeing. Considering mental health outcomes alongside the physical aspects of CAD management is essential for optimizing patient care and enhancing the success of PCI procedures.