Article Detail — Pakistan Science Abstracts

Choose Theme

Theme 1 — Green & Gold

No Detail Found!
Synthesis, X-Ray Crystallography and Anti-Inflammatory Evaluation of a Novel Thiosemicarbazide
Author(s)
Leena Anjum Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan; Research Institute of Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan
Asia Naz Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi,Karachi,PakistanResearch Institute of Pharmaceutical Sciences, University of Karachi,Karachi,Pakistan
Hina Shamshad Research Institute of Pharmaceutical Sciences, University of Karachi,Karachi,Pakistan
Abstract
An innovative thiosemicarbazide compound Methyl trimethoxy phenyl hexene thiosemicarbazide (MTHT) was produced by a single pot condensation reaction. Different techniques were used for structure elucidation including chromatography, spectroscopy, and X-ray diffraction. Furthermore, anti-inflammatory response of the synthesized compound was estimated by luminol enhanced chemiluminescence technique through reactive oxygen species. MTHT exhibited more potent antiinflammatory action with IC50 value of 08 ± 0.6 µg/ml in contrast to reference standard ibuprofen. Molecular docking was preferred for determination of possible binding interactions of synthesized compound with Phospholipase A2 protein. Additionally, biological activity was predicted through PASS virtual method
Publication Details
Page(s) 60-60
DOI DOI not available
Published Journal: Abstract Book on International Conference on Food and Applied Sciences (ICFAS-23) 3-5 August 23, Volume: 0, Issue: 0, Year: 2023
Keywords
molecular docking Virtual bioscreening Thiosemicarbazide Antiinflammatory agent XRay Crystallography
References
References are not available for this document.
Citations
Citations are not available for this document.
0

Citations

0

Downloads

35

Views

Copyright ©  PASTIC National Center, Islamabad www.pastic.gov.pk