Crateva adansonii (Capparaceae) is a very common medicinal plant in the Cholistan region of Pakistan that, according to local folk medicine, is considered useful in the treatment of gastritis and gastric ulcer. We have aimed to test the validity of this practice by using the experimental model of an ethanol-induced gastric ulcer in male Wistar rats. The results showed that Crateva adansonii had gastroprotective activity, that the hexane extract had the highest protective activity (70.38 ± 5.42%), and Lupeol isolated from this extract was the main active gastroprotector agent. In conclusion, Crateva adansonii contains compounds with gastroprotective activity. Lupeol, which was isolated from this plant, was the main compound with gastroprotective activity, having effectiveness similar to that found with the use of Ranitidine.