The resistance pattern of Staphylococci against beta-lactam group of antibiotics in Hyderabad, Pakistan | Rawal Medical Journal 2021

Author(s)

Shama Hashmani Institute of Microbiology, University of Sindh,Jamshoro, Pakistan

Bushra Bano Patoli Institute of Microbiology, University of Sindh,Jamshoro, Pakistan

Nimerta Kumari Institute of Microbiology, University of Sindh,Jamshoro, Pakistan

Atif Ahmed Patoli Institute of Microbiology, University of Sindh,Jamshoro, Pakistan

Shagufta Jabeen Institute of Microbiology, University of Sindh,Jamshoro, Pakistan

Abstract

Objective: To estimate the frequency of antibiotic resistance among the Staphylococci against a set of beta (ß) lactam group of antibiotics. Methodology: A total of 156 cultures of Staphylococci were isolated from clinical specimens and based on the coagulase production were categorized into two groups as; Coagulase Positive Staphylococci (CoPS) and Coagulase Negative Staphylococci (CoNS). The antibiotic resistance was determined using Kirby Baur disc diffusion method. Results: Out of 156 isolates 57.6% (n=90) isolates were from male patients while 42.4% (n=66) were from female patients. About 62.1 % (n=97) of the isolates were CoPS while 37.9 % (n=59) were CoNS. Among CoPS the highest percentage of resistance (97.9%) was observed against penicillin G whereas among the CoNS the highest resistance was observed against Cefixime (93.2%). The comparative analysis for their potential to resist various members of beta-lactam antibiotics between CoPS and CoNS suggested non-significant differences for majority of the antibiotics used in this study. Comparatively higher resistance against amoxicillin was seen for CoPS (92.7%) than CoNS (79.6%). The odd ratio (OR) and confidence interval (CI 95%) for amoxicillin resistance between CoPS vs CoNS was calculated to be: 3.28 ( 1.21 – 8.89), while the pvalues were determined to be 0.015 using chi square test of independence applying 2x2 contingency table. These values suggest a significant association of amoxicillin resistance with CoPS. Conclusion: In general, beta-lactam antibiotic resistance in Staphylococcal isolates is observed greater in Hyderabad as compared to the previously described resistance in other regions of Pakistan.

Publication Details

Page(s) 18-21

DOI DOI not available

Published Journal: Rawal Medical Journal, Volume: 46, Issue: 1, Year: 2021

Keywords

Staphylococcus Aureus betalactam antibiotics CoagulaseNegative Staphylococci CoNs

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