UV Spectrophotometric Method for Estimation of Moxifloxacin HCl in Tablet Dosage Form and Comparative Study of its Diefrent Brands | RADS Journal of Pharmacy & Pharmaceutical Sciences 2015

Author(s)

Somia Gul Faculty of Pharmacy, Jinnah University for Women Karachi, Pakistan

Fakhra Khalid Faculty of Pharmacy, Jinnah University for Women Karachi, Pakistan

Maheen Nafees Khan Faculty of Pharmacy, Jinnah University for Women Karachi, Pakistan

Muhammad Tanweer Alam Faculty of Pharmacy, Jinnah University for Women Karachi, Pakistan

Abstract

An accurate and economical spectrophotometric method for the estimation of Moxifloxacin HCl in tablet dosage form has been developed and validated. The comparative studies of its diefrent brands were assessed through evaluation of oficial and non oficial standards such as disintegration and dissolution with the specification of US pharmacopeia. The proposed developed method was based on the UV absorbance, 0.1 M HCl used as a solvent. In this method Moxifloxacin shows wavelength maxima at 294nm and method was validated as per ICH guidelines for linearity, precision and accuracy. This proposed method was successfully applied for the analysis of diefrent brands of Moxifloxacin tablets available in the market and recovery study also revealed that there was no interaction occurred from the excipients present in the tablet.

Publication Details

Page(s) 41-49

DOI DOI not available

Published Journal: RADS Journal of Pharmacy & Pharmaceutical Sciences, Volume: 3, Issue: 2, Year: 2015

Keywords

dissolution Validation Spectrophotometry Moxioflxacin disintegration

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