Xanthine oxidase inhibition by 5-aryledene N,N’-dimethylbarbituric acid derivatives. | Journal of Chemical Society of Pakistan 2013

Khalid Mohammed Khan HEJ Research Institute of Chemistry International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan

Momin Khan HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University Karachi, Karachi, Pakistan; Department of Chemistry, Abdul Wali Khan University, Mardan, Khyber Pakhtunkhwa, Pakistan

Aneela Karim HEJ Research Institute of Chemistry International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan

Muhammad Taha H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University Karachi, Karachi, Pakistan; Atta-ur-Rahman Institute for Natural Product Discovery, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, Bandar Puncak Alam, Selangor, Malaysia

Nida Ambreen HEJ Research Institute of Chemistry International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan

Anar Gojayev HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University Karachi, Karachi, Pakistan; Baku State University, Baku, Azerbaijan

Shahnaz Perveen Pakistan Council of Scientific & Industrial Research (PCSIR) Laboratories Complex, Peshawar, Pakistan

Muhammad Iqbal Choudhary HEJ Research Institute of Chemistry International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan

N,N’-dimethylbarbituric acid derivatives 1-24 were evaluated for their xanthine oxidase (XO) inhibitory activity. Majority of these compounds showed a good to moderate in vitro xanthine oxidase inhibitory activity (IC50 = 20.97 ± 0.29 - 327.0 ± 3.50 µM), while eight compounds were found to be completely inactive. A structure-activity relationship has been discussed, identifying structural features, responsible for varying degree of activity.