One and half years old baby boy admitted with history of high grade fever, dry cough and malaise for 05 days. He was given syrup Ibuprofen 100mg at home for fever resulting in swollen face, eye and rash on upper back next day. Erythematous rash progressed to involve nearly 30% of body surface area on 2nd day. Oral ulcers developed on 3rd day. Local practitioner instructed mother to keep him at rest and treat with hydration. CoAmoxiclav syrup was added whereas Ibuprofen was continued. Diagnosis of Toxic epidermal necrolysis secondary to ibuprofen was established upon presentation to CMH Multan.