The known medicinal effects of seaweeds have been known for thousands of years. Also, a wide range of recent studies have described the high antioxidant capacity of a range of edible seaweeds. In this review article, the application of seaweed antioxidants in foods, food supplements, nutraceuticals and medicine is considered from the perspective of benefits to human health. The underlying physiology of algal antioxidant compounds is reviewed in the context of seaweed biology and utilization. It is found that direct consumption of seaweed products for their antioxidant composition provides a useful alternative to non- natural substances, while simultaneously providing worthwhile nutritional benefits. Economic utilization of seaweeds for their antioxidant properties is also inquired. Overall, the review confirmed that seaweeds antioxidants have huge potential in providing major health benefits through subsequent investigative studies relating to this in literature.