5-Nitroimidazole derivatives and their antimicrobial activity. | Journal of Chemical Society of Pakistan 2016

Khalid Mohammed Khan HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi, Pakistan

Uzma Salar HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi, Pakistan

Saima Tauseef Department of Microbiology, Federal Urdu University of Arts, Science and Technology (FUUAST), Gulshan-e-lqbal, Karachi, Pakistan

Ghulam Abbas Miana Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan

Sahar Yousuf HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi, Pakistan

Farzana Naz HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi, Pakistan

Muhammad Taha Atta-ur-Rahman Institute for Natural Product Discovery, Universiti Teknologi MARA UiTM, Puncak Alam Campus, Bandar Puncak Alam, Selangor D. E. Malaysia; Faculty of Applied Science UiTM, 40450 Shah Alam, Selangor, Malaysia

Saifullah Khan Department of Microbiology, Federal Urdu University of Arts, Science and Technology (FUUAST), Gulshan-e-lqbal, Karachi, Pakistan

Shahnaz Perveen PCSIR Laboratories Complex, Karachi, Karachi, Pakistan

5-Nitroimidazole derivatives 2-8 were synthesized from secnidazole. The syntheses were accomplished in two steps which start from the oxidation of secnidazole to the secnidazolone 1. Secnidazolone 1 was converted into its hydrazone derivative 2-8 by treating with different substituted acid hydrazide. Compounds 2-8 were evaluated for their antimicrobial activity against Gram-positive and Gram-negative bacteria, compounds 3 and 4 showed the significant activity against Staphylococcus epidermidis, however, compound 2 showed good inhibitions against Corynebacterium diphtheria when compared with the standard. Compound 3 showed good inhibitory potential against tested Gram-negative bacterial strains i.E. Enterobacter aerogene, Escherichia coli, Salmonella typhi, Salmonella paratyphi A, Shigella flexeneri and Vibrio choleriae. All synthetic derivatives were also tested against eight fungal stains, however, they were weekly active against Aspergillus flavus and Candida albican. The synthesized compounds were characterized by different spectroscopy techniques.