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The Relationship Between the Expression of Tumor Associated Fibroblasts Cav-1 and MCT4 and the Prognosis of Papillary Carcinoma of Breast.
Author(s)
Li Cui Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou city, PR China
Miaomiao Sun Department of Pathology, Henan Cancer Hospital, Zhengzhou city, PR China
Zhihua Zhao Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou city, PR China
Jianping Yang Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou city, PR China
Yupeng Zheng Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou city, PR China
Lulu He Department of Pathology, The First Afiliated Hospital of Zhengzhou University, Zhengzhou city, PR China
Kuisheng Chen Department of Pathology, The First Afiliated Hospital of Zhengzhou University, Zhengzhou city, PR China
Qingxia Fan Medical Oncology, eTh First Afiliated Hospital of Zhengzhou University, Zhengzhou city, PR China
Abstract
Aim: To investigate the potential role of MCT4 in the progress of IMPC in CAFs. Methods: MCT4 and Cav-1 expression in 86 IMPC patients were detected by immunohistochemical LSAB methods and the 105 cases of non specific invasive ductal carcinoma (IDC-NOS) selected as the control. Compared the diefrences of the expressions of them in diefrent issues and analysed the relationship of the main pathological features of the expression of Cav-1 and MCT4 in diefrent ages, tumor stages and hisological grades. Results: The study conformed that the miss expression of Cav-1 on CAFs and the expression of MCT4 up-regulated were related on the poor prognosis of IMPC patients. Conclusion: It suggested that CAFs may be the target of the tumor and can supply the new basis for the treatment of breast cancer.
Publication Details
Page(s) 9-20
DOI DOI not available
Published Journal: RADS Journal of Pharmacy & Pharmaceutical Sciences, Volume: 4, Issue: 1, Year: 2016
Keywords
CAFs Cav1 Breast cancer MCT4
References
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