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The Relation Between Hypertension and Angiotensin Converting Enzyme Genotype in Iraqi.
Author(s)
Israa Adnan Ibraheam College of science for Women, University of Babylon, Babil, Iraq
Tsahel Hamed Al-dulaimi College of science for Women, University of Babylon, Babil, Iraq
Sabreen Kamal Abd alameer College of science for Women, University of Babylon, Babil, Iraq
Zainab Khudhur Ahmad Al-Mahdi College of Dentistry, University of Babylon
Hawraa Wahab Aziz College of science for Women, University of Babylon, Babil, Iraq
Amal Raqib Shimran College of science for Women, University of Babylon, Babil, Iraq
Abstract
The source of most common chronic condition attributed to high blood pressure or hypertension, which affect about 20%-30% of the adult males and female's population. The present study is aimed to determine the association, of angiotensin converting enzyme genotype with Iraqis' hypertensive patients. The study was carried out on 30 Iraqi patients having hypertension and 30 healthy subjects as control. Blood samples were collected from both patients and the healthy subjects, DNA from the patients and control specimens were isolated, Detecting of ACE insertion deletion genotype was done by polymerase chain reaction. The results show association between ACE genotype with hypertension DD genotype was increase in patients than control. The present study reported the relation between angiotensin converting enzyme genotype among Iraqis' hypertensive patients.
Publication Details
Page(s) 15-17
DOI DOI not available
Published Journal: Pakistan Journal of Biotechnology, Volume: 15, Issue: 1, Year: 2018
Keywords
Keywords are not available for this article.
References
Arnett D.K ., B.R.,Davis , C.E.,Ford,,2005,Pharmacogenetic association of the angiotensin-converting enzyme insertion/deletion polymerphism on blood pressure and cardiovascular risk in relation to antihypertensive treatment: The Genetics of Hypertension-Associated Treatment (GenHAT) study,Circulation,111,3374-3383
Borlay , A.J.,Suharsono,,2017,Development of single nucleotide polymorphisms (SNPS) marker for oleic acid content in oil palm (Elaeis guineensis Jacq,Pak. J. Biotechnol,14,55-62
Carretero O.A . and S.,Oparil,,2000,Essential hypertension. Part I: Definition and etiology,Circulation,101,329-335
Chung C.M.,R.Y.Wang,J.W.Chen,,2010,A genome-wide association study identifies new loci for ACE activity: Potential implications for response to ACE inhibitor,Pharmacoge-nomics,10,537-544
Deepika , N.L.N.,K.R.Reddy,M.Balakrishna,K.P.PrasannaLatha and J. Parveen,,2013,Do ACE I/D gene polymorphism serve as a predictive marker for age at,PCOS? J. Assist. Reprod. Genet,30,125-130
Ehret G.B.,,2010,Genome-wide association studies: Contribution of genomics to understanding blood pressure and essential hypertension,Curr. Hypertens. Rep,12,17-25
Fayyad , H.A.D.,I.H.Aziz,,2015,Genetic polymerphism of angiotensingen gene in high blood pressure,World Journalof Pharmacy and Pharmaceutical Sciences,4,1910-1917
William J. He , Changwei,Li , Dabeeru C.,Rao,,2015,Shimmin, Dong-feng Gu and Tanika N. Kelly, Associations of Renin Angiotensin Aldosterone System Genes with Blood Pressure Changes and Hypertens-ion Incidence,American Journal of Hyper-tension,28,1310-1315
Hermida R.C. , D.E.,Ayala , R.,Fernández,,2011,Circadian rhythms in blood pressure regulat-ion and optimization of hypertension treatm-ent with ACE inhibitor and ARB medications,Am J Hypertens,24,383-391
Higaki J. , S.,Baba , T.,Katsuya , N.,Sato , K.,Ishikawa , T.,Mannami , J.,Ogata and T.,Ogihara,,2000,Deletion allele of angiotensin-con-verting enzyme gene increases risk of essen-tial hypertension in Japanese men: the Suita Study,Circulation,101,2060-2065
Miller J.A.,J.W.Scholey,,2004,The impact of reninangiotensin system polymorphisms on physiological and pathophysiological processes in humans,Curr. Opin. Nephrol. Hypertens,13,101-106
KonoshitaT.,,2011,Do genetic variants of the reninangiotensin system predict blood pressure response to renin-angiotensin system-blocking drugs? A systematic review of pharmacogenomics in the renin-angiotensin system,Curr. Hypertens Rep,13,356-361
RigatB.,C. Hubert , F.,Alhenc-Gelas , F.,Cambien , P.,Corvol and F.,Soubrier,,1990,An insertion/ delet- ion polymorphism in the angiotensin I-conv-erting enzyme gene accounting for half the variance of serum enzyme levels,J. Clin. Invest,86,1343-1346
RukavinaMikusic,N.L.,N.M.Kouyoumdzian,,2018,Effects of chronic fructose overload on renal dopaminergic system: alteration of urin- ary Ldopa/dopamine index correlates to hypertension and precedes kidney structural damage,Journal of Nutritional Biochemistry,51,47-55
Schelleman H. , O.H.,Klungel,C.M. Van,,2006,Drug-gene interaction between the insertion/deletion polymorphism of the angiotensin-converting enzyme gene and antihypertensive therapy,,40,212-218
Schelleman H. , O.H.,Klungel,C.M. van Duijn,,2005,Insertion/deletion polymorphism of the ACE gene and adherence to ACE inhibitors,Br. J. ClinPharmacol,59,483-485
TaverneK.,M. de Groot,,2010,Gene-tic polymorphisms related to the renin-angiotensin-aldosterone system and response to antihypertensive drugs,Expert Opin. Drug Metab. Toxicol,6,439-460
ThielB.,A.B. Weder,,2000,,J. Clin. Hypertens,2,187-193
TsukadaK.,T.Ishimitsu,N.Tsuchiya,S , Hori-naka and H. Matsuoka,,1997,Angiotensin-conver-ting enzyme gene polymorphism and cardio-vascular endocrine system in coronary angio-graphy patients,Jpn Heart J,38,799-810
Yu H.,Y.Zhang,,2003,Relationship betw-een polymorphism of the angiotensin-conve-rting enzyme gene and the response to angio-tensinconverting enzyme inhibition in hyper-tensive patients,Hypertens. Res,26,881-886
ZhuX.,Y.P.Chang,D.Yan,,2003,Associations between hypertension and genes in the reninangiotensin system,Hypertension,41,1027-1034
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