Abstract:
The field of topical drug delivery systems has currently advanced significantly with the advent of nanotechnology, leading to the development of targeted drug delivery to the site of action, resulting in enhanced bioavailability. In this study, we aimed to develop a topically applied nanoemulgel containing cetirizine and evaluated its anti-allergic activity for management of urticaria using an animal model. Incorporating polymeric networks into nanoemulgel allows for controlled drug release and enables particle size customization for specific formulations. Our results demonstrated that the optimized nanoemulgel formulation has a pH ranging from 5.1 to 6.1 which lie in the acceptable range for topical preparations. It had adequate viscosity ranging from 7830cP to 8001cP to prevent sedimentation or creaming, even after 28 days of preparations and had optimized spreadability, which may aid in the easy application of the dosage form. The Fourier-transform infrared (FT-IR) study revealed no incompatibility between the drug and excipients. Zeta potential analysis of the developed formulation revealed a value of -13.9 mV, and the particle size was in the submicron range. In-vitro analysis demonstrated promising drug release, and the drug content was found to be 96.6%, which complies with official limits. In vivo study results indicated that the cetirizine-loaded nanoemulgel formulation is highly effective in treating urticaria with localized action compared to standard drugs. These findings suggest that the cetirizine nanoemulgel could be a valuable treatment option for cutaneous urticaria. Additionally, the development process for the nanoemulgel provides insights into the development of other active drugs loaded topical formulations.
Page(s):
95-95
DOI:
DOI not available
Published:
Journal: Abstract Book on International Conference on Life Sciences (ICLS-23) 11-12 May 22-23, Volume: 0, Issue: 0, Year: 2023
Keywords:
cetirizine
,
carbopol
,
Urticaria
,
Topical Drug Delivery
,
Nanoemulgel