Vernonione, a new urease inhibitory Carvotacetone derivative from Vernonia cinerascens. | [Journal of Chemical Society of Pakistan • 2012]

Author(s):

1. Irshad Ahmad: Faculty of Pharmacy & Alternative Medicine, The Islamia University of Bahawalpur-63100, Pakistan

2. Muhammad Ashraf: Faculty of Pharmacy & Alternative Medicine, The Islamia University of Bahawalpur-63100, Pakistan

3. Bashir Ahmad Chaudhary: Faculty of Pharmacy, Bahauddin Zakariya University Multan, Pakistan

4. Muhammad Uzair: Faculty of Pharmacy, Bahauddin Zakariya University Multan, Pakistan

5. Khalid Hussain Janbaz: Faculty of Pharmacy, Bahauddin Zakariya University Multan, Pakistan

Abstract:

Vernonione, a new 7-deoxycarvotacetone derivative 1, together with three known sesquiterpene lactones; vernolide A, C (2,3) and potamopholide (4) has been isolated from the methanolic extract of the roots of Vernonia cinerascens. The structure 3ß-acetoxy-5a-angeloyloxy- 7-deoxycarvotacetone was established by using UV, IR, 1H and 13C-NMR spectra (DEPT), 2D-NMR analyses (COSY, HMQC and HMBC experiments) in combination with HRFAB-MS, HREI-MS experiments and in comparison with literature data of related compounds. Compound 1 showed inhibitory potential against enzyme urease in concentration dependant fashion with IC50 value 227.6 µmol.

Page(s): 639-642

DOI: DOI not available

Published: Journal: Journal of Chemical Society of Pakistan, Volume: 34, Issue: 3, Year: 2012

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