The Impact of Sleeve Gastrectomy on Inflammatory Markers and Immune Response: A Study of Cytokine Changes, Weight Loss, and Insulin Resistance | [Journal of Pioneering Medical Sciences • 2025]

Author(s):

1. Wasnaa Jomaa Mohammed: Department of Basic Sciences, College of Nursing, University of Baghdad,Baghdad,Iraq

Abstract:

Objectives: This study aim to assess how individuals who had gastric bypass surgery or sleeve gastrectomy changed in terms of their blood cytokine levels. Methods: A total of 40 patients who are having bariatric surgery and have a BMI greater than 35. Gastrectomy patients were divided into three groups: those who had the procedure before to surgery, those who had it three months after, and those who had it six months after. Demographic information, weight, BMI, blood sugar, CRP levels, and cytokine levels of IL-1ß, IFN-a, IFN-?, a, MCP-1, IL-23, and IL-33 at the time of hospitalisation and six months after surgery. Results: Preoperative interleukin-1 beta (IL-1ß) levels in patients were significantly elevated compared to concentrations measured at 3 months (1.39±0.82 mg/dL) and 6 months (0.74±0.13 mg/dL) post-surgery (2.64±0.9 mg/dL, P<0.001). Furthermore, a statistically significant difference was observed between the two postoperative groups (3-month vs. 6-month follow-up, P<0.001). Similarly, preoperative concentrations of interleukin-12 (IL-12) and interleukin-23 (IL-23) were markedly higher than levels detected at both 3 and 6 months post-surgery. A significant disparity in IL-12 and IL-23 levels was also noted between the 3-month and 6-month postoperative cohorts (P<0.001). The current findings indicate a considerable rise in IL-33, IFN-a, and IFN? in patients before to surgery as compared to both groups after surgery. However, no statistically significant difference was observed between the two postoperative groups (3-month vs. 6-month follow-up) (P<0.05). Moreover, human monocyte chemoattractant protein-1 (MCP-1) showed no significant difference across all groups. Conclusion: The current study shown that weight reduction after bariatric surgery also results in a regression in inflammation, which may be linked to the inflammasome.

Page(s): 106-112

DOI: 10.47310/jpms2025140414

Published: Journal: Journal of Pioneering Medical Sciences, Volume: 14, Issue: 4, Year: 2025

Keywords:

Obesity , Sleeve gastrectomy , Cytokine , Gastric bypass

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